Get 11th Annual meeting of the EBMT: European Cooperative Group PDF

By Th. Büchner (auth.), W. Hinterberger, A. J. Barrett, K. Lechner, E. Deutsch (eds.)

ISBN-10: 3662393999

ISBN-13: 9783662393994

ISBN-10: 3662404575

ISBN-13: 9783662404577

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Sus ceptibili ty t o infec tio ns was somewha t i n creased during t he fi rs t year a f ter ABMT. 4/ 9 patient s ha d mi l d herp es zos t e r . No severe i nfe c t i ons , ho we ver , we r e observed . Long-te rm to xi city was o bser ved more ft> equentl y in pa ti ents recei ving purged marrow ( 3/5 pa ti ents) as compare d t o pa t ients r ecei ving untreated marr ow (1 / 4 pati ents) . In view o f t he h e t e r ogenei t y o f ob served loarterm s equelae, a s pecifi c t oxic effec t o f t he purging pro cedure appears to be unlikel y.

05). * TBI was associated with the best survival over chemotherapy alone CTBI : 33 patients, 62% survival at 5R3 days - chemotheropy : 13 patients, 30% survival at 346 days. 05). Ol). * Marrow cleansing was not associated with improvement both from DFS and survival anolysis, neither in CRl nor in CR2. Althouqh the difference is not statistically siqnificant, there seems to be a trend in favour of autoqraftinq with non purqed marrow in patients in CR1. l)(not statistical1y significant). D - COMPARISON BETWEEN ALL AND ANLL : By DFS analysis, results were significant1y better for ANLL (79% versus 50%, on day 560 with a plateau until1 day RR7 for both.

If used details on marrow cleansinq procedure including, for treatment with cyclophosphamide derivatives, the precise dose per number of treated cells. - Course and follow-up including the status of the patient in relation to leukemia, infectious complications, cause of death. B - POPULATION OE PATIENTS : 148 charts from 15 European institutions were collected. 5 institutions reported more than 10 patients. The median age of patients submitted to ABMT was 26 years, 22 y in ALL (range 2 - 55) and 32 Y in ANLL (2- 53).

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11th Annual meeting of the EBMT: European Cooperative Group for Bone Marrow Transplantation by Th. Büchner (auth.), W. Hinterberger, A. J. Barrett, K. Lechner, E. Deutsch (eds.)


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